Rapid Vienna find themselves bottom of Group H heading into Thursday, having won just once so far which has led to this being a must-win match.
The hosts will be unable to qualify if they lose against the Hammers, no matter what the result is in the other fixture and even a victory might not be enough to keep their dreams alive.
A Dinamo Zagreb win would end Vienna’s hopes of qualifying, but they must concentrate on their match as they attempt to pick up their second three points.
Dietmar Kuhbauer’s team were able to defeat Zagreb in the third round of matches, due to finishes from Marco Grull and Maximilian Hofmann as they earned a 2-1 victory.
However, defensively they have struggled at times in this group, having conceded seven goals so far in the competition, which is a concern against West Ham.
David Moyes has watched his side find the back of the net on nine different occasions in the Europa League so far, with two of those coming against Rapid Vienna.
The Hammers defeated their opponents 2-0 in the reverse fixture, with Declan Rice and Said Benrahma both on target, despite the fact they did not have the lion’s share of possession.
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However, West Ham have been ruthless in their performances so far in Europe, which is why they have already qualified for the knockout stage of the competition.
Despite that, Moyes will be wanting more from his team after they were held to a draw in their most recent outing in this group against Genk.
Even though Benrahma scored a brace, they ended up conceding a late own goal from Tomas Soucek which saw the spoils shared on the night.
West Ham were also defeated at the weekend against Wolverhampton Wanderers which is a result and performance they will want to put behind them