Pirates head coach Josef Zinnbauer has revealed that injury-prone strikers Tshegofatso Mabasa and Zakhele Lepasa will be unavailable this weekend.
While Richard Ofori and Thembinkosi Lorch are expected to shrug off their respective minor injuries and face Swallows.
Bucs will pin their hopes of securing a win over the Beautiful Birds on Lorch, who looked sharp and hungry against Chiefs earlier this month.
Pirates remain the only side in the history of the PSL to have retained their Top 8 title the following season having done so 10 years ago in 2011.
Meanwhile, Swallows head coach Brandon Truter has confirmed that they will be without Tlakusani Mthethwa with the player having sustained an anterior cruciate ligament injury.
The influential central midfielder is likely to be sidelined for the entire 2021/22 season, while Mwape Musonda is also doubtful due to lack of match fitness.
Pirates loanees Austin Muwowo and Monnapule Saleng are expected to face their parent club and they have what it takes to haunt the Buccaneers by inspiring the Beautiful Birds to a win.
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Swallows have won the Top 8 trophy three times and the last time they lifted the title was in 2012 and it was their last appearance in the competition.
Bucs have recorded seven outright wins (plus one via penalties) compared to five (plus one via penalties) for the Beautiful Birds, while five matches ended in draws.Overall,
the two Soweto rivals have met in 79 matches across all competitions since 1985.Pirates have 30 wins compared to 17 for Swallows, while no less than 32 games have been drawn.