Cambridge scraped past National League North side Curzon Ashton on penalties last time out, to book their place in the FA Cup second round.
The two sides could not be split over 180 minutes of action, but it was the League One outfit that remained composed from the spot.
Joe Ironside, Jack Lqankester, Harvey Knibbs and Paul Digby all found the target from 12 yards for Cambridge, to set up a home tie with League Two club Grimsby Town on November 26.
Mark Bonner’s side have struggled in league action this season, as they currently sit 18th in the table, six points clear of the relegation places.
The Yellows have only scored 18 goals in their opening 18 games, and their last result in the league was a respectable 0-0 draw with seventh-placed Bolton Wanderers.
Bonner will fancy his team’s chances on Saturday, coming up against an Accrington Stanley side that are below them in the table, and have only won two games on their travels this season.
However, Cambridge have not won at the Abbey Stadium in the league since they beat Lincoln City 2-0 on September 3.
Meanwhile, Accrington Stanley have only picked up one point in their last seven league games leaving them in 20th place in League One, just three points clear of the relegation places.
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The Reds lost narrowly to promotion-chasing Sheffield Wednesday last weekend, courtesy of a first-half strike from Alex Mighten.
Stanley’s last victory in the league was a 3-0 win over Morecambe back at the start of October, and the early indications are that John Coleman’s side could be involved in a relegation battle in the third tier this season.
Coleman will be hoping that his team can build on their last victory away from home, which was a 4-1 victory against Crawley Town in the FA Cup first round.
Shaun Whalley celebrated his first senior hat-trick to fire Stanley into the second round, where the Reds will host Barnet, but league results will be the priority for Coleman and his staff.
