After suffering back-to-back first-round exits, Wycombe are competing in round two for the first time since the 2020-21 season.
The Chairboys claimed a narrow 2-1 away win over fourth-tier Bradford City earlier this month to set up a second-round tie against another League Two side.
Matt Bloomfield’s side may be pleased to have the distraction of a cup fixture after failing to win any of their last seven league matches (D3, L4).
They have lost each of their previous three games in League One, including Tuesday’s meeting with Barnsley, which resulted in a 1-0 loss after Sam Crosgove found the net in stoppage time to snatch all three points.
With their attention set to turn to Saturday’s cup fixture, the hosts will be concerned by their recent home form, having won just one of their last five competitive matches at Adams Park (D1, L3).
Morecambe, meanwhile, have experienced a recent change in manager after Derek Adams decided to leave the club and return to Scotland for a third spell with Ross County.
Ged Brannan and John McMahon were subsequently placed in interim charge, overseeing a demoralising 6-0 away defeat to League Two promotion hopefuls Wrexham.
Following the forgettable trip to North Wales, the Morecambe hierarchy opted to give Brannan the manager’s job on a full-time basis.
In his first game as permanent manager, Brannan saw his side lose 2-1 to Newport County in Tuesday’s home fixture despite the fact that Morecambe took the lead through Michael Mellon.