In one of the most peculiar fixtures in the Premier League so far this season, there is huge jeopardy on it for both.
It is one that all neutrals will be keeping an eye on given the magnitude of what the result could mean for both clubs and their respective managers.
David Moyes and Frank Lampard are currently the two favourites to be sacked due to the fact their clubs are currently both in the bottom two of the form table.
Over the last seven matches, West Ham have picked up just one point, while Everton have collected two.
It has emerged in the last week that Moyes could be relieved of his dutiesshould he lose here.
That is despite comfortably taking his side through as group winners in the UEFA Europa Conference League earlier in the season, but Premier League survival remains paramount given the financial benefits it will bring.
After winning six on the bounce at home, West Ham have followed it up by losing four in a row at the London Stadium, all against sides they would expect to beat, especially on home soil.
If West Ham were to find a win, though, it could spell the end for Lampard at Everton, but what is most surreal is that Moyes will be one of the favourites to take over from him at his old club.
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Discontent among the Everton supporters has reached an all-time high following the fallout from their match with Southampton last week.
A protest from the supporters was overshadowed by allegations from their own board of assault and death threats being made towards members, something which has dominated headlines given the conflicting reports given from both sides.
Supporters are understandably irate given the lack of communication and the underachievement seen under the current board, as a second successive relegation battle is on the cards despite spending in excess of £500 million in the last half-decade.
