Wigan are currently on a remarkable 20-match unbeaten run in all competitions, which has propelled them into the automatic promotion mix in League One.
The run also includes FA Cup wins over Solihull Moors, Colchester United and then Championship side Blackburn Rovers in round three.
This is the Latics’ first appearance in the fourth round since 2018 and since famously beating Manchester City to win the 2013 final, they have only reached round five on two occasions.
Leam Richardson’s side have the best away record in League One this season and have only lost twice on the road throughout the whole campaign.
Wigan won 3-0 in the last fixture between these two sides when they met in the Championship in June 2020 – the Latics’ points deduction for going into administration relegated them three weeks later.
Stoke eased past League Two outfit Leyton Orient with a 2-0 win in the third round, ending a staggering run of six years without a victory in the FA Cup.
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The Potters, who were runners-up to Manchester City in 2011, have made it past round four only once in the last nine seasons.
Michael O’Neill’s side have faded away from the Championship top-six picture in recent weeks as they are winless in their last three matches.
Meanwhile, they have won just one of their last six games at the bet365 Stadium – which was the third round victory over Orient
