Both of these clubs will be keen to consign the 2022-23 campaign to history as quickly as possible, with Liverpool and Southampton having suffered hugely-underwhelming seasons to varying degrees.
For Liverpool, the damage was done in the first two-thirds of the season, although they will take some positivity into the summer having seemingly turned the corner with an ongoing 10-match unbeaten streak.
That included a seven-game winning run which came to an end at Anfield against Aston Villa last time out – a result which left their already-slim Champions League hopes hanging by a thread.
Manchester United then delivered the final blow by cruising past Chelsea on Thursday night to put the top four beyond reach, leaving Liverpool to play Europa League football next term as a result of their lowest finish in any of Jurgen Klopp’s seven full seasons in charge.
Klopp was keen to stress that fifth is still a good result considering where they sat just a couple of months ago, but there is no doubt that a rebuild is required at Anfield in the transfer market this summer, particularly in midfield.
Before that, a Liverpool side more used to battling for the Premier League title on the final day in recent years will look to end a disappointing campaign on a high despite nothing tangible depending on the match.
The Reds have won three Premier League away games on the trot to suggest that their travel sickness is now behind them, having only won three of their first 15 on the road this season, losing eight of those. Indeed, should Liverpool win on Sunday then almost half of their away points for the entire campaign would have come in their final four such games.
Klopp’s side have also scored 11 goals in those three successive wins – as many as they had in their previous 13 away games – and they will be confident of bolstering that tally further against a team that has already shipped 69 goals this season.
Indeed, Liverpool could hardly have hand-picked a better final-day opponent having won 10 of the last 11 league meetings against Southampton, and conceding only five goals in their last 13.
Liverpool have also won each of their last six games on the final day of a season, stretching back to 2015-16, whereas Southampton have lost their last two and now find themselves in very real danger of suffering three such defeats in a row for the first time since a run of seven which ended in 1939.