Luton made it three wins in their last four matches in all competitions on Saturday when they recorded a 3-0 victory at Cambridge United to progress to the fifth round of the FA Cup.
Nathan Jones’s side have only lost one of their last eight in the Championship, meanwhile, which has included three wins in their last five matches against Reading, Bristol City and Swansea City.
Last time out in the league, Luton secured all three points against Swansea at the Liberty Stadium courtesy of a second-half effort from Harry Cornick.
A total of 42 points from 28 matches has left the Hatters in ninth position in the table, just three points behind sixth-placed West Bromwich Albion, with a number of sides currently battling to break into the top six.
Luton, who finished 12th in the second tier last term, recorded a 1-0 victory over Barnsley in the reverse match earlier this season, while they have only lost one of their last six games against Tuesday’s opponents.
Barnsley, meanwhile, will enter the contest off the back of a 1-0 defeat to Huddersfield in the fourth round of the FA Cup on Saturday afternoon.
The Tykes, who finished fifth in the Championship last season, are currently bottom of the division, having only picked up 14 points from their opening 28 matches of the campaign.
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There is no getting away from the fact that it has been a desperately disappointing season for the club, who are eight points from the safety of 21st position and are showing no signs of potentially moving out of trouble.
Barnsley have actually lost each of their last five in the Championship and are without a victory since the start of November, when they managed to overcome the team directly above them in the table, Derby County.
Now under the management of Poya Asbaghi, the strugglers will be bidding to record just their third league victory of the campaign on Tuesday evening, but they have only managed 17 league goals all season and have lost three of their last five Championship games against Luton.