Ipswich have the chance to claim consecutive victories after they extended their unbeaten run to six matches with a 2-0 win over Exeter City at the weekend.
Freddie Ladapo opened the scoring in the 11th minute before Marcus qHarnesswrapped up the three points with a second-half strike.
Saturday’s victory leaves Ipswich in second position in League One, but they will put their promotion push on hold as they turn their attention to the EFL Trophy.
Despite finishing level on six points with Arsenal Under 21s and Cambridge United, the Tractor Boys topped the group due to their superior goal difference.
Having already beaten Portsmouth 3-2 at home earlier in the season, Ipswich will be confident of progressing to the third round.
Meanwhile, Portsmouth are currently unbeaten in seven games in all competitions, but they would have been disappointed to slip out of the League One playoff places at the weekend.
Pompey had to settle for a point on Friday after their home meeting with Derby finished goalless, which represented their fourth consecutive league draw.
Despite struggling to convert draws into victories, Danny Cowley’s have won two of their previous three competitive away games, which will inspire confidence ahead of Tuesday’s contest.
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They are also still yet to lose an EFL Trophy game in 90 minutes this term, although they had to settle for second place in their group after picking up six points from three matches.
Pompey have already won and lost a penalty shootout in the competition this season, and they will look to draw upon that experience if penalties are required against Ipswich.
The hosts are unable to call upon the services of Dominic Ball and Tyreece John-Jules, with the pair set to miss out through injury.Although Kieran McKenna will be keen to progress to the last 16, he is expected to rotate his side, with
Vaclav Hladky, George Edmundson and Kane Vincent-Young all set to feature.Kayden Jackson could also be brought into the starting lineup, and he will be looking to add to the two goals that he has scored this season.
