Both of these clubs are previous winners of the FA Cup, with Barnsley lifting the trophy in 1912 and Huddersfield doing so 10 years later.
This is the Terriers’ first appearance in the fourth round since 2018 after they knocked out Premier League strugglers Burnley in round three.
Carlos Corberan’s side trailed 1-0 against the Clarets, but goals in the final 16 minutes of the game from Josh Koroma and Matty Pearson completed a stunning turnaround at Turf Moor.
Huddersfield were in action in midweek as they beat Derby County 2-0 on Wednesday night to move back into the Championship playoffs.
It is now 11 matches without defeat in all competitions for the Terriers and they are on their longest unbeaten run in the second tier of English football since 1965.
In contrast, Barnsley have lost four successive matches – most recently against Cardiff on Wednesday night – and are eight points adrift of safety in the Championship.
Poya Asbaghi’s only win in his 11 games in charge so far came in the previous round of this competition, when the Tykes squeezed past League Two side Barrow with a thrilling 5-4 victory after extra time.
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The South Yorkshire outfit are yet to win away from home this season and have lost nine of their last 10 matches on the road.
This is the club’s third successive season in the FA Cup fourth round after going six years without getting past round three; last season, they reached the fifth round before losing to Chelsea.
For any fans looking for a glimmer of hope, Barnsley are unbeaten in their last four matches against Huddersfield; the two sides played out a 1-1 draw at Oakwell in their league meeting earlier this season