Cheltenham have adapted well to life in the third tier of English football after earning promotion from League Two last season.
The Robins find themselves in mid-table after 14 games, and they will be content with their campaign so far despite seeing a two-game winning run ended by defeat at Doncaster Rovers last weekend.
After going 3-0 down, Liam Sercombe missed his spot kick for The Robins, before Alfie May and Andy Williams scored, but it was all too little too late for the visitors.
In midweek, their focus turned to the EFL Trophy, when after a goalless draw, Cheltenham earned an extra point by beating Chelsea Under-21s on penalties.
They will look to continue their fine home form when they turn their attention back to League One on Saturday, with Cheltenham having lost only once in their last six league games at Whaddon Road.
Sheffield Wednesday have only lost three times in League One this season, but six draws in 14 league encounters has hindered their bid to return to the Championship at the first time of asking.
In fact, The Owls have drawn their previous three fixtures, with the most recent of those coming at home to Lincoln City last weekend.
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Dennis Adeniran gave the hosts the lead early in the second half, but Lewis Montsma scored to ensure that Sheffield Wednesday would experience a 1-1 draw for the second game in a row.
If Darren Moore’s side are to collect a victory at the weekend, then Lewis Gregory will be key, with the striker top scoring for The Owls this season with five league goals to his name.
In keeping with the theme of the season so far, Sheffield Wednesday have drawn half their away league encounters, but they can take positives from the fact they are unbeaten in their last five away games in all competitions